Warum kein Verapamil bei Herzinsuffizienz?
8 Kontraindikationen Verapamil darf nicht eingenommen werden bei dekompensierte Herzinsuffizienz, AV-Block höher als Grad I, Vorhofflattern und Vorhofflimmern mit Präexzitationssyndrom, Sick-Sinus-Syndrom, kardiogenem Schock der auf eine andere Ursache als Arrhythmie zurückzuführen ist.
Warum keine calciumantagonisten bei Herzinsuffizienz?
Kurzwirksame Calciumantagonisten verschlechtern Prognose Der Einsatz von Calciumantagonisten bei Patienten mit Herzinsuffizienz ist aufgrund ihrer zum Teil auftretenden negativ inotropen Wirkung kritisch zu betrachten.
How does verapamil work in the cardiovascular system?
How it works. Verapamil affects the passage of calcium ions across cell membranes of smooth muscle cells and heart (myocardial) cells. When used to treat angina, verapamil dilates the main coronary blood vessels and reduces how much energy and oxygen the heart uses to beat.
How is verapamil used to treat tachyarrhythmias?
Because verapamil does not increase airways resistance it can be used in patients with obstructive airways disease. The drug is also effective in supraventricular tachyarrhythmias following open-heart surgery and myocardial infarction. 3. It is not an effective drug against ventricular arrhythmias unless due to coronary artery spasm.
Are there any side effects to taking verapamil?
In addition to its own adverse effects, verapamil can also interact with a wide variety of other drugs. The most frequent adverse effect of verapamil is constipation. In some people, verapamil can cause dizziness, light-headedness, and hypotension. In cases of overdose, verapamil interferes with the rhythm of the heart and can lead to loss of life.
When is the peak level of verapamil reached?
Response and effectiveness Peak levels of verapamil are reached one to two hours after oral administration. Peak levels may be increased in people with liver disease or of an older age. 7.