Was ist Hepatorenal Syndrome?
Das hepatorenale Syndrom (HRS) ist ein funktionelles Nierenversagen bei akuter oder chronischer Hepatopathie. Beim HRS Typ 1 verschlechtert sich die Nierenfunktion innerhalb weniger Tage, 95 Prozent der Patienten versterben ohne Lebertransplantation innerhalb weniger Wochen.
Warum können bei einer Leberzirrhose die Nieren versagen?
Im Rahmen der fortgeschrittenen Leberzirrhose besteht in der Regel gleichzeitig Flüssigkeit in der Bauchhöhle (Aszites). Die Nierenfunktionsstörung rührt von einer verminderten Durchblutung her. Durch die Lebererkrankung kommt es zur Drosselung der Blutzufuhr der Nieren.
What does hepatorenal syndrome stand for?
Hepatorenal syndrome (HRS) is a type of progressive kidney failure seen in people with severe liver damage, most often caused by cirrhosis. As the kidneys stop functioning, toxins begin to build up in the body.
What are the differential diagnoses for hepatorenal syndrome?
One of the tests used to diagnose HRS is a common blood test known as a serum creatinine test . The test measures the level of creatinine in the blood, and the results reflect how well the kidneys are functioning. One of the signs of HRS is an abnormally high level of creatinine in the blood.
How is hepatorenal syndrome (hrs) diagnosed?
The diagnosis of hepatorenal syndrome is based on laboratory tests of individuals susceptible to the condition. Two forms of hepatorenal syndrome have been defined: Type 1 HRS entails a rapidly progressive decline in kidney function, while type 2 HRS is associated with ascites (fluid accumulation in the abdomen) that does not improve with standard diuretic medications.
What is the prognosis of hepatorenal syndrome (hrs)?
The prognosis of individuals with type 1 HRS is particularly grim, with a mortality rate exceeding 50% after one month. Patients with type 1 HRS are usually ill, may have low blood pressure, and may require therapy with drugs to improve the strength of heart muscle contraction ( inotropes) or other drugs to maintain blood pressure ( vasopressors ).