Was bewirkt Vidaza?
Vidaza entfaltet seine Wirkung, indem es Krebszellen daran hindert, zu wachsen. Azacitidin wird in das genetische Material der Zellen (die Ribonukleinsäure (RNA) und die Desoxyribonukleinsäure (DNA)) eingebaut.
Was kostet Vidaza?
Vidaza 25 Mg/ml Plv. H.e.Inj. -Susp. 100mg
| Packungsgrößen | UVP/AVP | Preis** |
|---|---|---|
| 1 St. | 490,32 € | 10,00 € |
Wie wirkt Azacitidin?
Bei dem Azacitidin handelt es sich um ein zytostatisch wirkendes, pharmakologisch genutztes Analogon des Nukleosids Cytidin. Dabei macht man sich die zytostatische Wirkung von Azacitidin in der Chemotherapie von Leukämie zu Nutze. Die Entwicklung und das Wachstum von malignen Zellen wird somit vermindert.
When was Vidaza first approved for the treatment of MDS?
In May 2004, Vidaza became the first drug approved by the FDA for the treatment of patients with Myelodysplastic Syndromes (MDS). The FDA approved Vidaza, the first in a new class of drugs called demethylation agents, for treatment of all five MDS subtypes, which include both low-risk and high-risk patients.
Is there a cure for myelodysplastic syndrome with Vidaza?
No, Vidaza or azacitidine does not cure myelodysplastic syndrome. The only potential cure for myelodysplastic syndrome is allogeneic stem cell transplantation but unfortunately, most patients diagnosed with myelodysplastic syndrome are elderly people with other comorbidities therefore, most of them are not candidates for transplantation.
What was the median survival of Vidaza patients?
In the primary endpoint analysis, Vidaza treatment was associated with a median survival of 24.4 months versus 15 months for those receiving CCR treatment, an improvement of 9.4 months with a stratified log-rank p-value of 0.0001.
How does Vidaza work to kill cancer cells?
(High doses). Vidaza is a ribonucleoside, so, it incorporates more into RNA than to DNA. The cytotoxicity is imposed on the rapidly dividing cells which include cancer cells that are not responding to the normal cell growth mechanisms and the drug destroy these cells.