Wie wirkt daptomycin?
Daptomycin wirkt bakterizid. Das Lipopeptid wird Calcium-abhängig in die Zellmembran von grampositiven Bakterien eingebaut. Dadurch kommt es zur Ausbildung von Membranporen, durch die vor allem Kalium-Ionen ausströmen. Damit entsteht eine Depolarisation des Membranpotentials.
Wie wird daptomycin aufgelöst?
Daptomycin Accord wird intravenös in einer 0,9%igen Natriumchloridlösung verabreicht (siehe Abschnitt 6.6). Daptomycin Accord sollte nicht öfter als einmal täglich angewendet wer- den.
Does daptomycin cause nephrotoxicity?
Compared to other antibiotics with a similar antibacterial spectrum, daptomycin does not cause nephrotoxicity. Taking these and other characteristics into consideration, daptomycin appears to be a good alternative to other drugs used in the treatment of complicated skin and soft tissue infections and in Gram-positive bacteremial infections.
Is daptomycin expensive?
♦ Data on dosing and safety are lacking in patients with kidney impairment. ♦ The drug cost for daptomycin ( Cubicin ) is $165 per day. This is more expensive than other alternative treatments such as vancomycin ($92.54), cloxacillin ($0.70-$14.40) and linezolid ($141.28).
What does daptomycin mean?
Here are all the possible meanings and translations of the word daptomycin. Daptomycin is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms. It is a naturally occurring compound found in the soil saprotroph Streptomyces roseosporus.
How much is daptomycin?
This daptomycin price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies. The cost for daptomycin intravenous powder for injection 350 mg is around $241 for a supply of 1 powder for injection, depending on the pharmacy you visit.